Scientific Publications Exercise Research Paper

Scientific Publications Exercise - Research Paper Example ar dynamics simulations have shown that interactions of lipid head groups with the protein is with the help of weak charge and hydrogen bond interactions. A set of exchange reactions governs the effective binding of lipid molecules usually defined by equilibrium constant. Thus the annular site on a protein membrane bilayer containing PC and PS mixture would be occupied by either a PC or a PS molecule Author were trying to prove that the anionic lipids could significantly effect the functioning of channels. This is evident from the explanations on the lipid phosphatidylserine which made the channels active irrespective of phosphatidylcholine being present in large numbers. The conclusion is inadequate to establish their claims. Though the author is of the opinion that binding to large charge clusters could influence the anionic lipids on the channel function , they also believe that the collective influence of the physical properties of the lipid layer cannot be ruled out. It was suspected earlier that an infectious agent was associated with the initiation of cancer in any normal cell. After one hundred years of research it is established that the viral, bacterial or a parasitic infection had a definite role in the human carcinogenesis. Further, the estimates have shown that the proportion of vulnerable cancer cases could also be reduced to a level of 20 percent if particular infectious agents could be eliminated. The enquiry to explore where the infectious agent causing cancer is partially answered in the case of Merkel cell carcinoma. Some of the carcinoma condition was developed after having infected with epidemic like AIDS. The research results presented in this paper explain that just detecting the microbial genome cannot confirm the incidence of cancer. Also, it is proposed that no one can infect a person with the causative agent and then wait for any signs of incidence of cancer. Thus the authors confirm that the evaluation method that assigns specific

Working capital trade-offs of. Porsche AG, Daimler AG, and BMW Coursework

Working capital trade-offs of. Porsche AG, Daimler AG, and BMW - Coursework Example This section would be discussing the working capital trade-offs of three luxury car manufacturing companies Porsche AG, Daimler AG, and BMW. Porsche AG is a German luxury car company which was established in the year 1931. The company generated â‚ ¬10,928 million in the year 2011 as revenue. The working capital of the company was estimated to be around â‚ ¬65.8 billion in 2011, which was derived from the receivable from the customers, increasing leasing and renting charges of assets, etc (Volkswagen AG, 2011). Porsche AG met its working capital requirement through credit from banks when they were in Volkswagen Group (Porsche Automobil Holding SE, 2013). However, now the net liquidity position has improved with a 15 percent rise in sales and about 21 percent rise in the return on equity. So it can be said that Porsche no more has to rely on bank credits for working capital, but the company in 2011 negotiated with banking syndicate for extending a credit of â‚ ¬2.5 billion. This reveals that Porsche AG has to trade profitability for liquidity because the working capital requirement for running operational function is more important than investing the working capital. The company was running short of cash or cash equivalents due to which they had to keep provisions for credit from banks (Porsche SE, 2011). Daimler AG another luxury car company which has many luxury car brands under its business, such as Mercedes-Benz, Maybach, Mitscubishi Fuso, and many more. The company was established in 1998 in Stuttgart, Germany. Revenue generated by Daimler AG in 2011 was â‚ ¬106.54 billion, and it was able to earn a profit of â‚ ¬5.667 billion in 2011, during the ongoing economic slowdown. The liquidity amounted to â‚ ¬11.9 billion in 2011, while the same was â‚ ¬13 billion in 2010. The decreasing liquidity is due to the extensive cash outflow for the pension plan assets, and also for the acquisition of the share of Tognum AG. Daimler AG is defensive in this regard, as it chooses to maintain liquidity and control credit risk exposure (Daimler, 2011). The company traded liquidity for profitability and for this Daimler AG also raised funds to finance the cash requirements of the company (Daimler, 2011). BMW is a German automobile company which was established in 1916. BMW stands for Ba yerische Motoren Werke AG. BMW is also the parent company of the most luxurious car called Rolls Royce and it also produces Mini marquee. The revenue earned by the company in 2011 was â‚ ¬68.82 billion and the operating income was about â‚ ¬8.006 billion. The net profit of the company increased in 2011 by â‚ ¬4,907 billion, which lead to increased cash inflow of the company by â‚ ¬1,664 billion. However, the changing working capital has decreased the cash flow from the operating functions by â‚ ¬1,212 million. This is because of increase in stock and introduction of new models of cars. So the working capital trade-off of BMW revealed that liquidity was traded for profitability. The company minimized the amount of working capital in order to invest them for launching new models of cars, after

Universal healthcare the only answer Essay Example | Topics and Well Written Essays - 1500 words

Universal healthcare the only answer - Essay Example Healthcare is a human right, also in the Constitution under life liberty and the pursuit of happiness, but many Americans do not feel its benefits. Universal healthcare is the only answer because it will also save money. â€Å"We can eliminate wasteful inefficiencies such as duplicate paper work, claim approval, insurance submission, etc. We can develop a centralized national database which makes diagnosis and treatment easier for doctors† (Universal, 2009). There are many reasons to support universal healthcare supported by community health principles. Universal healthcare is about representing a true community healthcare principle of access for all, not just for all who can afford it. In terms of base arguments, supporters of national healthcare tend to argue that there should be a single-payer system in which healthcare is financed by the government but the government does not take control of the system in a way that diminishes privatized options. But on the other hand, â€Å"The current crisis in the U.S. healthcare system may be more one of perception than fact. While it is true that in certain areas of the country and for some segments of the population there are real healthcare access and coverage problems, coverage is available in most places and for most individuals. The magnitude of the crisis may not be significant enough to justify the major changes in the healthcare delivery system that will result from present reform proposals† (Kalkhof, 1994). It is the recommendation of this report that the current system of managed care observed at modern healthcare facilities should be changed from a consumer-based platform to a patient-based platform in which there is universal coverage and a renewed attention to upholding patient rights. â€Å"According to principles of American paternalism, no American should go without food and water, shelter, clothing, sanitary facilities, protection, physically and legal, equal opportunity,

Applying Thermal Expansion Essay Example for Free

Applying Thermal Expansion Essay Complete the following problems and exercises using complete sentences and showing all work where appropriate. 1. The temperature of the Suns interior is about 107 degrees. Does it matter whether this is degrees Celsius or kelvins? Defend your answer. No, it DOESNt matter whether this is in degrees Celsius or kelvins, since the DIFFERENCE between these scales is ONLY ~ 273 of either measure, and that is ABSOLUTELY NEGLIGIBLE w.r.t. the magnitude of the number 10^7. However, what is more important, perhaps, is that your value of 10^7 is itself a rather loose characterization. Modern  solar evolutionary models suggest rather that the Suns T_c is ~ 1.5 x 10^7 (degrees Celsius or kelvins) instead of merely ~ 10^7. (Our understanding of solar physics is certainly such that an error of a factor of ~ 1.5 in its central temperature would be considered way out of all reasonable possibility!) Of course the numerical factor in front of 10^7 would matter even more if one were using the (non-scientific) Fahrenheit scale. Once again, however (unlike National Geographic magazine, which should hang its head in shame over some of its conversions), one would NOT say that the Suns central temperature was about 2.7 x 10^7 and 32 degrees Fahrenheit! 2. What happens to the gas pressure within a sealed gallon can when it is heated? Cooled? Why? The gases in general obey the gas laws. As per the law the pressure,volume and temperature of the gas is related as: P1V/T1 =P2V2/T2; WhereP1 is pressure at stage 1, V1 is volume at stage 1 and T1 is temperature (Kelvin) for stage 1,and P2,V2 and T2 are the pressure,volume and temperature for stage 2. Now, if a gas contained in a sealed gallon is heatedor cooled the volume of the gas is constant but pressure and temperature will adjust u=in such a way that the : P1/T1 =P2/T2 If T2 is more than T1,then( heating the gas ) P2= P1*T2/T1 as T2 T1 so P2 will bve more than P1,hence, the pressure will increase. If T2

Switzerland and the European Union Essays -- switzerland, republic, ca

Officially known as the Swiss Confederation, Switzerland is a federal parliamentary republic comprised of 26 cantons, which represent four languages and a population of just over eight million . Switzerland is well known for its small landmass yet high standard of living, as well as its banking system and adherence to traditional Swiss culture. While the state is autonomous, it is a part of the Schengen Area unlike all EU members, and remains outside of the European Union (EU) and the European Economic Area (EEA), as it became the sole EFTA member to reject membership by referendum in 1992 . Despite this, Switzerland maintains a staunch economic relationship with members of the EU through a series of bilateral agreements involving trade, free movement of people, agriculture and taxation among others. These provisions between countries provide an increasingly interdependent European continent characterized by trade agreements, free movement of Swiss-EU citizens and a single European market. A recent referendum against mass immigration has passed through Switzerland’s direct democracy by a majority of just 50.3% , effectively nullifying the bilateral agreements that were reached with the EU in 1999. The referendum is binding in Switzerland and requires the Swiss Federal Council to produce legislation within three years of the vote. As a result, officials within the EU have voiced their regrets regarding the outcome of the ballot, and are carefully considering re-evaluating their relations with Switzerland. The issue of Switzerland’s proposed cap on immigration is a very recent matter, and the results of the referendum will likely be a catalyst for changes in EU policies. This paper will examine steps that the European Union cou... ...immigration." Le Temps, September 2011. Ryser, Monique. Bilateral Agreements Switzerland-EU. Edited by Integration Office FDFA/FDEA. Bern, Switzerland: Department of Foreign Affairs FDFA, 2009. Schwok, Renà ©. Switzerland - European Union: An Impossible Membership? Brussels: European Interuniversity Press, 2009. Taylor, Paul, and Richard Mably. "Switzerland Can't Have It Both Ways on Migration: EU's Barroso." Reuters (Brussels), February 12, 2014. Accessed March 2014. http://www.reuters.com/article/2014/02/12/us-eurozone-summit-switzerland-idUSBREA1B0FG20140212. Telegraph staff and agencies. "France ready to 'roll out the red carpet' for British exit from EU." The Telegraph (England), January 23, 2013. Accessed March 2014. http://www.telegraph.co.uk/finance/financialcrisis/9820327/France-ready-to-roll-out-the-red-carpet-for-British-exit-from-EU.html.

Hadoop

Its a platform managed under the apache software foundation and its an open source and its deal with big data with any data type structer semi structer or unstructers and give the result in very short time it allows to work with structured and unstructured data arrays of dimension from 10 to 100 gb and even more. V.Burunova and its structer is a group of clusters or one each of them contains groups of nodes too and each cluster has two type of node name node and data node name node is a unique node on cluster and it knows any data block location on cluster and data node is the remining node in cluster and that have done by using a set of servers which called a cluster. Hadoop has two layers cooperate together first layer is mapreduce and it task is divided data processing across multiple servers and the second one is hadoop distributed file system hdfs and its task is storing data on multiple clusters and these data are separated as a set of blocks. Hadoop make sure the work is correct on clusters and it can detect and retrieve any error or failure for one or more of connecting nodes and by this way hadoop efforts increasing in core processing and storage size and high availability. Hadoop is usually used in a large cluster or a public cloud service such as yahoo. Facebook twitter and amazon hadeer mahmoud 2018 hadoops features: Scalable: Hadoop able to work with huge applications and it can run analyze store process distribute large amount of data across thousands of nodes and servers which handle thousands terabytes of data or more also it can add additional nodes to clusters and these servers work parallel. Hadoop better than traditional relational database systems because rdbms cant expand to deal with huge data. Single write multiple read the data on cluster can be read from multiple source at the same time data avalibility: When data is sent to a data node that hadoop creates multiple copies of data on other nodes in the cluster to keep data available if there a failure on one of nodes on cluster.

Pricing Program

In this research it was tried to analyze perspectives of activity of the Galaxy Science Centre (GSC), located in the city of Britannia. Taking into consideration the status of the GSC a non-profit consideration, the study analyses the admission fee policy for various groups of visitors.The special attention in the work is given to the achievement of the objective â€Å"raising public interest in science†, combined with the goal to provide a financial self-sufficiency of the institutions. The research contains also an analyze of possible various promotion programs implementation.Case study – Pricing ProgramThe Galaxy Science Centre (GSC) represents a non-profit organization, which is the first science museum to serve the city of Britannia. Using quick approach, two issues below should be resolved:To determine the admission rate for the first year To determine the admission policy after the first year of operation Organization / Market Environment AnalysisBasic SWOT and P orter’s Five Forces analysis indicate that the GSC’s unique position as the city’s only science museum, along with the municipality’s backing and the support of the school board, could give competitive advantages to the GSC. In such situation the GSC could be one of the most exciting places to visit in the city.However, there is a possibility of an existing major competition, which may originate from other entertainment institutions in the city. The museum’s demands for continuous municipal funding would also limit GSC’s capabilities for a further expansion. The details of the analysis can be found in appendix 1.Goals, Objectives and their Relationship to Various Project PartiesThe mandate provided by the board of trustees represents four major goals that the GSC should achieve. Unfortunately, taking into consideration financial and informational constraints as discussed above, it is unlikely that the museum will meet all the expectations eq ually well.Therefore, it is recommended that the GSC goals should be ranked according to their importance. As shown and discussed in appendix 2, the top priority of the GSC activity is to educate the general public, while an achievement of financial objectives can be sacrificed. The ranking, used in appendix 2, implies that customers (the general public) are the most critical project parties and their demands and wants should be considered as the primary ones.Alternatives and Analysis1. First Year Revenues, Costs and Admission RateAs indicated in the market study[1], the demand is relatively inelastic, and the expected total admissions number is not likely to vary substantially both at the admission price of $ 0.0 and at the price of $6.5. Moreover, an establishment of the admission price of $6.5 may lead to the GSC downfall, especially during the first year of activity (appendix: table 1). Therefore, only admission prices above $6.50 should be considered as market reasonable option s.It should be noted that no reliable market data is available in the case of the price above $6.5 and such admission price could lead to an unexpected drop in total admissions. However, when the price of $6.5 is benchmarked against other options of entrance fees (see appendix 3), it appears to exist some space for a higher admission price than $6.5 per visit.2. Admission Policy for Year 2 and BeyondOption #1: Admit Seniors and Pre School Children Free of Charge and Increase Promotion and Advertising Expenditures by $200,000As demonstrated in appendix: table 2, the investment of $200,000 is expected to bring an average return of $309k. Such investment will also likely to draw townsmen to the GSC which should pursue the objective of raising the public interest in science. The downside of this strategy lies in the fact that the GSC will most likely perceive financial losses. An expected annual profit may vary from -$1.2m to $621k, with an expected value of -$367k.Option #2: Charge a D iscounted Admission Price for Senior Citizens and Pre-school KidsWhen charging a discounted admission prices for seniors and children it may lead to the upraise of incomes extra sources. By that, a following important factor should be considered. In the most cases seniors and children are not likely to visit the GSC themselves, and often such visits are just â€Å"tagged-along† to some family events.The discount tickets may be effective when they are accompanied with the extra charges for adults or students. On the other side such extra charges for adults and students may have a bad effect on the admission income.Option #3: Admit Seniors and Pre School Children Free of Charge and Convince the Municipality to Continue the SubsidyFree money is always great,   Ã¢â‚¬â€œ providing the municipal annual investments in amount of $1m, the GSC will not need to worry about the balance sheet in the foreseeable future. This option, if combined with the advertisement investment in option #1, would provide the GSC an opportunity to make huge profits. However, such passive approach is a deviation from the original goal of the museum activity that the GSC is meant to be a self-sufficient institution.[1] Second paragraph, exhibit 2 in the case